New product from Cayman Chemicals
Cholesterol Trafficking and Metabolism
Cholesterol is an essential structural component of cells and an early intermediate in the synthesis of steroid hormones and bile acid. However, serum cholesterol is thought to be a key factor leading to the development of vascular diseases such as atherosclerosis. Be it to monitor normal or disease processes, Cayman has a convenient group of tools for studying cholesterol absorption, trafficking, and metabolism.
New Cholesterol Uptake Cell-Based Assay Kit (catno.: 600440) »»
Other Cholesterol Trafficking products:
CatNo |
Description |
Brand |
Category |
Application |
Amount |
Price |
Cart |
|---|---|---|---|---|---|---|---|
| 13220.S1 | C-12 NBD Cholesterol | Cayman Chemicals | Biochemicals | N/A |
500 ug | € 74.00 | |
| 13220.S2 | C-12 NBD Cholesterol | Cayman Chemicals | Biochemicals | N/A |
1 mg | € 141.00 | |
| 13220.S3 | C-12 NBD Cholesterol | Cayman Chemicals | Biochemicals | N/A |
5 mg | € 595.00 | |
| 13220.S4 | C-12 NBD Cholesterol | Cayman Chemicals | Biochemicals | N/A |
10 mg | € 1042.00 | |
| 13221.S1 | 3-hexanoyl-NBD Cholesterol | Cayman Chemicals | Biochemicals | N/A |
250 ug | € 69.00 | |
| 13221.S2 | 3-hexanoyl-NBD Cholesterol | Cayman Chemicals | Biochemicals | N/A |
500 ug | € 131.00 | |
| 13221.S3 | 3-hexanoyl-NBD Cholesterol | Cayman Chemicals | Biochemicals | N/A |
1 mg | € 250.00 | |
| 13221.S4 | 3-hexanoyl-NBD Cholesterol | Cayman Chemicals | Biochemicals | N/A |
5 mg | € 1111.00 | |
| 500001.S1 | Lipid Droplets Fluorescence Assay Kit | Cayman Chemicals | Assays/RIA/ELISA/EIA/Complete kits | N/A |
480 tests | € 217.00 | |
| 10007640.S1 | Cholesterol Assay Kit | Cayman Chemicals | Assays/RIA/ELISA/EIA/Complete kits | N/A |
96 wells | € 136.00 |
Prostaglandin D2 (PGD2) is biosynthesized in the brain by a soluble, 26 kDa glutathione-independent lipocalin-type PGD2 synthase. This PGD2 accumulates in the cerebrospinal fluid (CSF), where it induces physiologic sleep in rats and humans. PGD2 is also synthesized in mast cells and leukocytes by a cellular, myeloid-type, glutathione-dependent PGD synthase. This PGD2 which is formed in the intracellular and vascular compartments is rapidly metabolized to 11beta-PGF2alpha and other metabolites. Measurement of the parent eicosanoid PGD2 is appropriate in cell culture lysates and in CSF, where concentrations of several hundred pg/ml have been measured. Cayman's PGD2 EIA Kit is a competitive assay that can be used for quantification of PGD2 in cell culture lysates and enzymatic reactions.
Prostaglandin D2 (PGD2) is biosynthesized in the brain by a soluble, 26 kDa glutathione-independent lipocalin-type PGD2 synthase. This PGD2 accumulates in the cerebrospinal fluid (CSF), where it induces physiologic sleep in rats and humans. PGD2 is also synthesized in mast cells and leukocytes by a cellular, myeloid-type, glutathione-dependent PGD synthase. This PGD2 which is formed in the intracellular and vascular compartments is rapidly metabolized to 11beta-PGF2alpha and other metabolites. Measurement of the parent eicosanoid PGD2 is appropriate in cell culture lysates and in CSF, where concentrations of several hundred pg/ml have been measured. Cayman's PGD2 Express EIA Kit is a competitive assay that can be used for quantification of PGD2 in cell culture lysates and enzymatic reactions. This EIA offers the convenience of a fast assay with a two hour incubation time and one hour development time, while still achieving an B/B0 value (50% IC50) of approximately 1,300 pg/ml and a detection limit (80% IC50) of approximately 350 pg/ml.
a-Linolenic Acid-d14
Cayman Chemical Item Number
9000433
Synonyms
ALA-d14
Formal Name
9Z,12Z,15Z-octadecatrienoic acid-d14
Description
α-Linolenic acid-d14 (ALA-d14) contains fourteen deuterium atoms at the 2, 2’, 3, 3’, 4, 4', 5, 5', 6, 6', 7, 7', 8, and 8' positions. It is intended for use as an internal standard for the quantification of ALA by GC- or LC-mass spectrometry (MS). ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.
Eicosanoid Mass Spectrometry Kit
Cayman Chemical Item Number:
710000
Synonyms:
GELB Derivitization Kit
Description:
Many lipids have a free carboxylic acid group that typically requires a weak acid mobile phase to ensure retention by HPLC. Unfortunately, the presence of the acid in the mobile phase also suppresses anion formation and often leads to poor electrospray ionization and poor MS sensitivity. The Cayman’s AMP+TM Mass Spectrometry Kit contains a positively charged reagent (AMP+) that can be coupled quantitatively to free carboxylic acids through an amide bond linkage. The resulting derivatized product thus contains a positively charged group that shows improved electrospray ionization and consequently improved MS sensitivity. Cayman’s derivatization reagent is stable to MS/MS fragmentation and thus isobaric derivatives undergo compound-specific fragmentation to give unique fragment ions.
Caspase-14 Monoclonal Antibody (Clone 70A1426) NEW
Cayman Chemical Item Number
13916
Formulation
100 µg protein G-purified IgG in 200 µl PBS containing 0.02% sodium azide
Specificity
Human Caspase-14
Murine Caspase-14
Description
Antigen: synthetic peptide corresponding to mouse caspase-14 amino acids 2-18 · Host: mouse · Application(s): FC and WB · Peptide sequence: amino acids 2-18 · Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.1 The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into an a2b2 tetramer to form the active enzyme. Caspase-14 has a conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis.
PtdIns (4)-P1-fluorescein (ammonium salt) exclusive NEW
Cayman Chemical Item Number:
9000655
Formal Name:
1-(1-octadecanoyl-fluorescein-2R-octadecanoylphosphatidyl)inositol-4-phosphate, tritriethylammonium salt
Description:
The phosphatidylinositol (PtdIns) phosphates are membrane phospholipids that play critical roles in the generation and transmission of cellular signals. PtdIns-(4)-P1-fluorescein consists of PtdIns-(4)-P1 conjugated with fluorescein. Fluorescent phosphoinositide derivatives can be used both in vitro and in a range of cell types following delivery with polyamine carriers.
Eicosapentaenoyl Serotonin exclusive NEW
Cayman Chemical Item Number:
9000640
Formal Name:
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-5Z,8Z,11Z,14Z,17Z-eicosapentaenamide
Description:
Eicosapentaenoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Item No. 70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with eicosapentaenoic acid have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
