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Proteintech Europe Ltd.

Proteintech Group Inc.

Proteintech Group, Inc richt zich op het ontwikkelen en produceren van een breed spectrum van antistoffen tegen alle menselijke eiwitten, en het verstrekken van de meest effectieve instrumenten voor de identificatie en de kwantificatie van het grote aantal bekende en onbekende ziekte markers. Proteintech Group biedt een verscheidenheid van monoklonale en polyklonale antilichamen voor uw onderzoek. Elk antilichaam is grondig getest op een aantal applicaties namelijk immunoprecipitatie, immunoblotting en immunohistochemie, zodat u ze met vertrouwen kunt gebruiken. Omdat we weten dat elk antilichaam zijn unieke toepassingen en functies heeft, voorziet Proteintech bovendien hun klanten van complete technische ondersteuning en gedetailleerde instructies voor elke toepassing.

Belangrijkste Productlijnen:

Antilichamen
Fusieproteïnen
Lysaten
Premade Westerns
Full length cDNA klonen

Meer informatie kunt u vinden op: www.ptglab.com

Featured products

Neuroscience: The STIM1 Antibody »»

Focus on PLSCR1 »»

Focus on SMYD3 »»

Focus on NUDT6 »»

Focus on RAC2

Rac2, along with Rac1 and Rac3, belongs to a family of Rho guanosine triphosphatases (GTPases). Almost all Rho family GTPases, including the Rac family, stimulate actin polymerization within the cell – regulating changes in cytoskeletal structure affecting cell shape, migration and adhesion.

Rac2 is found exclusively in cells of hematopoietic origin and is important in their development; it controls hematopoietic stem/progenitor cell retention in bone marrow which is critical to the homeostasis of blood cell production. Mice homozygous for Rac2 deletions develop microcytic anemia with a haemoglobin drop of about 20% and enhanced haemolytic processes [1]. Read more »»

ProteinTech IFITM Antibodies

Proteintech antibodies help uncover the role of IFITM proteins in the innate immune response. Proteintech interferon-induced transmembrane (IFITM) antibodies are helping scientists investigate the body’s natural defense mechanisms against viruses such as H1N1 and HIV-1. The antiviral properties of the IFITM proteins had been largely overlooked until late 2009, when the findings of a genome-wide RNA interference screen were published in Cell (1). This study identified the IFITM proteins as potent inhibitors of Influenza A, H1N1, West Nile and Dengue viruses. Following this, a separate group confirmed IFITM2 and IFITM3 antiviral activity against the latter two viruses revealing the role of the two proteins in disrupting virus entry into the cell (2). This last paper featured Proteintech antibodies in its Western blot experiments.

Related antibodies:

# 11727-3-AP rabbit polyclonal IFITM1
# 12769-1-AP rabbit polyclonal IFITM2
# 60074-1-Ig mouse monoclonal IFITM1
# 11714-1-AP rabbit polyclonal IFITM3

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Proteintech is a company based on superior science; 95% of our antibodies are raised against whole protein antigens, producing all-purpose antibodies that recognise your protein of interest in any application.

Alzheimer’s disease signaling pathway

Alzheimer’s disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta, a major component of senile plaques, has various pathological effects on cell and organelle function. Extracellular amyloid-beta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular amyloid-beta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function and triggering calcium dysfunction. To date, genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of amyloid-beta peptides, specifically the more amyloidogenic form, amyloid-beta 42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.

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Anti-RRM1 antibody

RRM1 (ribonucleotide reductase subunit MI) protein is the regulatory subunit of the heterodimeric enzyme, ribonucleotide reductase. In humans it is encoded by the RRM1 gene, located on chromosome segment 11p15.5. This region is significant in the development of non-small-cell lung cancer (NSCLC) as it is typically inactivated during NSCLC oncogenesis. More than 70% patients with NSCLC are diagnosed at the advanced stages of the disease meaning diagnostic and prognostic markers for its improved treatment are essential.

Related antibodies: