Potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). Displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.

Cat: 3578  10 mg   129€
Cat: 3578  50 mg   549€

Potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.

Cat: 3677  10 mg  €149
Cat: 3677  50 mg  €639

Potent and selective ERβ receptor agonist (Ki = 7.1 nM, EC50 = 4.8 nM). Displays 62-fold selectivity over ERα.

Cat: 3523 10 mg  €139
Cat: 3523 50 mg  €599