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Imgenex

IMGENEX develops novel reagents for the scientific study of human biology and disease and for the production of new diagnostic assays and potential therapies of such diseases. These novel reagents include antibodies, gene and protein expression systems and arrays of various cells and tissues for use in studies of functional genomics. Areas of biological interest at Imgenex include cancer, apoptosis, molecular signaling pathways, cellular aging and metabolic and infectious diseases.

 

Major Product Lines:

  • siRNA Interference
  • Cytokines and Chemokines 
  • NF-kB Pathway 
  • Toll-like Receptors
  • DNA Methylation and Repair
  • Retroviral Expression Systems

For more information, please visit: www.imgenex.com

 

Toll-like Receptors

Toll-like Receptors

The GateKeepers of Innate Immunity
Innate immunity as the first line of defense


The innate immune system is an ancient host defense mechanism found in almost every multicellular organism from plants to humans. In invertebrates it is the sole mechanism of defense against pathogens but in higher vertebrates constitutes the first line of defense.

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DAMPs: HMGB1, Alarmins and other Endogenous TLR Ligands are Sensors Linking Necrosis and Apoptosis to Regulation by the Innate Immune System

DAMPs: HMGB1, Alarmins and other Endogenous TLR Ligands are Sensors Linking Necrosis and Apoptosis to Regulation by the Innate Immune System

It is well-known that damage-associated molecular pattern molecules or DAMPs are released by necrotic or dying cells. DAMPs released into extracellular space by necrotic cells  include HMGB1, Heat Shock Proteins and S100 proteins and lead to inflammatory pathology exemplified by autoimmune disease sites¹.  In the case of HMGB1, its engagement with TLR2, TLR4 or RAGE triggers signaling through NF-kB pathways leading to pro-inflammatory cytokine release such as TNFa or IL-6 among others. Recently it has...

Products HMGB1 Antibody:

  • IMG-6738,
  • IMG-6739,
  • IMG-6740,
  • IMG-6655A,
  • IMG-6666A
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IHC Validated Antibodies

IHC Validated Antibodies

IMGENEX IHC Validated Antibodies include an expanding listing of polyclonal and monoclonal antibodies to add to our market leading product offering for Immunohistochemistry. Our IHC Validated Portfolio includes both commodity clones as well as IMGENEX original classic antibodies.

  • Apoptosis: BAD, Bax,  Bcl-2, Caspases, Smac/Diablo, Survivin
  • Cancer & Related Markers: β-Catenin, Cyclins, Estrogen Receptor, Myc, p53, p70, PKC, Progesterone Receptor, PTEN, STATs, VEGF
  • Dendritic Cells: BDCA-2, DC-SIGN, Dectin-2, MIP3α CLEC9A
  • Epigenetics: DNMT1, DNMT3a, DNMT3b
  • Neurosciences: Dopamine Receptors, GPCRs, HT Receptors, GABA Receptors
  • Stem Cell & development Biology: Transcription Factors, SOX2, Frizzled, KLF4, Myc
  • T Cells & T Cell Subsets: Tregs and Th17 related markers, RORy/RORy(t), IL-23R, EBI3, Bcl-6, IL-17A, IL-17F, ZAP70
  • TLRs, Innate & Adaptive immunity: TLRs, HMGB1, CD Markers, EBI3, Cytokine and Chemokine Receptors
  • Inflammation: IL-17A, IL-17F, HMGB1, NALP1, NALP2, NALP4, RAGE
  • Tissue Microarrays (TMAs): TMAs for specific cancers - Breast, Ovarian, Prostate, Lung and normal tissues
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Featured products

Featured products

»» Reporter Cell Lines

»» MyD88 New Monoclonal Antibody

»» Monoclonal Antibody to Noxa

»» Monoclonal Antibody to FOXP3A2 (exon 2 deleted) specific (Clone 16J4G6)

Apoptosis, Cell Death & Survival Mechanisms

Apoptosis, Cell Death & Survival Mechanisms

Cell death is a fundamental aspect of the life cycle of the eukaryotic cell. Homeostasis implies a balance between cell proliferation and cell death, and this balance is essential for the development and maintenance of multicellular organisms.

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Download here...

  • Apoptosis brochure »»
  • Apoptosis Pathway Poster »»
  • Cancer brochure »»
  • CD Markers brochure »»
  • Cell Death Pathway Poster »»
  • Chromatin Associated brochure »»
  • Dendritic Cell brochure »»
  • Flow Cytometric brochure »»
  • GeneSuppressor RNA Interference Products brochure »»
  • HISTO-Array Tissue Microarrays & Single Tissue Slides brochure »»
  • Human Clinical Tissue Lysates brochure »»
  • IHC Validated Antibodies brochure »»
  • Innovated Inhibitor Products for Research brochure »»
  • Neuroscience brochure »»
  • NF-kB brochure »»
  • Peptide Inhibitor brochure »»
  • Phosphospecific Antibodies brochure »»
  • Regulatory T Cell brochure »»
  • Toll-Like Receptors poster »»

Annexin V-FITC Apoptosis Kit with Controls

News

Redefining the Role of Caspases

Redefining the Role of Caspases

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INSTA-Blot™

IMGENEX introduces INSTA-Blot™ ready-to-use membranes, which provide a simple and cost-effective solution for screening the expression of a particular protein in different tissues and cells with various treatments.

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Breast Cancer Exploratory

Inflammation/Immune Response Pathways Initialized