Reinnervate

Reinnervate continues to develop new and innovative ways to manage the growth and function of cultured cells. Our products will improve the performance, reproducibility and relevance of in vitro cell-based assays.
Reinnervate was established in June 2002 to commercialise technology developed by its founding scientist Professor Stefan Przyborski working in the field of cell biology but with a particular interest in stem cell biology and developmental neuroscience. Reinnervate specialises in the development, manufacture and marketing of products for 3D cell culture, cellular growth and the production of small tissue-like structures. Alvetex^® has many applications in basic research and product development in the academic, health care, biotechnology and pharmaceutical sectors. The Company’s headquarters are located at NETPark Sedgefield England and include state-of-the-art research, development and production facilities.

For more information, please visit: www.reinnervate.com

What is 3D cell culture?

3D cell culture is about creating suitable surroundings for optimal cell growth, differentiation and function by:

Allowing individual cells to maintain their normal 3D shape and structure with minimal exogenous support and interference,
Encouraging cells to form complex interactions with adjacent cells and receive and transmit signals,
Enabling a more natural environment to foster the creation of native architecture found in tissue structures,
Reducing stress and artificial responses as a result of cell adaptation to flat, 2D growth surfaces.

Maintaining long term 3D cultures

In 3D cell culture there are many more cells per unit volume of medium which may require users to refresh their media more frequently, depending on the demands of the cells being cultured. We have designed a novel well insert holder to fit inside a deep Petri dish. By combining alvetex^® well inserts with the holder in the Petri dish, cells can be cultured in 3D for longer term assays reducing the requirement for frequent media changes. The holder can accommodate up to three 6 and/or 12 well inserts at any one time. In addition, the user can control the height of the insert within the Petri dish. Your 3D culture can be positioned at three different levels depending on the goals of your particular assay.

Key benefits:

Convenient – reduces frequency of media changing
Highly versatile and maximises user applications
Ideal for long term 3D culture experiments of up to several weeks
Petri dish facilitates use of magnetic stirrer to increase media circulation
Alternative insert heights give users better control over medium volumes
Raise 3D cultures up to the air liquid interface (e.g. skin application)
If required, up to 80ml of medium can used to support a single 3D culture

Alvetex product formats

Introduction:
To address the needs of our customers, reinnervate has launched several new presentations of alvetex^® providing the end user with a number of versatile options. These include multi-well plates, well inserts, and a large medium reservoir.

Highlights	Key benefits
By choosing from a range of different formats, the user can now match the presentation of alvetex to the requirements of the experiment These formats have been designed to enable flexibility, to optimise 3D cell growth using alvetex technology	Match the format of alvetex^® to optimise the growth of specific cell types Control the degree of penetration required within the 3D structure of alvetex^® Select the appropriate format to the duration of the assay and enable long term 3D cell culture

Multi-well plate format:	Well insert format:
alvetex® is available in a 12-well plate format. Each disc of alvetex® is held in place by a plastic clip which can easily be removed if necessary.	alvetex® is available in 6 and 12 well insert formats. The 12-well insert has extended wings that can snap back, enabling it to fit into both 6 and 12 well plates.
Key benefits:	Key benefits:
Ideal for 3D culture in the top half of alvetex^® Multi-well plate format is good for short term cultures Cells are fed from the top of the alvetex^® scaffold only Useful for when restricted cell penetration is required (e.g. transfection) An option for use with expensive cells, reducing cell numbers	Enables cells to be fed from above and below simultaneously Ideal for longer term 3D culture Supplied individually blister packed and compatible with standard plates Readily transfer 3D cultures to a fresh plate Enables co-culture studies (2D and 3D; or 3D and 3D)

: 2D culture & 3D culture

Products

CatNo	Description	Brand	Category	Application	Amount	Price
AVP002	Alvetex 12 well plate	Reinnervate	Media/Cell Culture Sera/Additives	N/A	1 plate	€ 94.00
AVP004-3	Alvetex 6-well inserts	Reinnervate	Media/Cell Culture Sera/Additives	N/A	3 inserts	€ 54.00
AVP005-3	Alvetex 12-well inserts	Reinnervate	Media/Cell Culture Sera/Additives	N/A	3 inserts	€ 46.00
AVP015	Alvetex well insert holder and petri-dish	Reinnervate	Media/Cell Culture Sera/Additives	N/A	1 set	€ 38.00

Reinnervate

What is 3D cell culture?

Maintaining long term 3D cultures

Key benefits:

Alvetex product formats

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