Prothrombin Deficient plasma (search for the: FII-ID-1)

Prothrombin is a vitamin K-dependent plasma protein that is synthesized in the liver (1). The mature single chain protein circulates in plasma as a zymogen and, during coagulation, is proteolytically activated to the potent serine protease α-thrombin. This proteolysis is catalyzed by the prothrombinase enzyme complex. During activation, human prothrombin is cleaved at Arg273-Thr274 and at Arg323-Ser324 to yield a "pro" fragment (fragment 1.2) and thrombin, the latter of which is composed of two chains covalently linked by a disulfide bond.

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