Inflammatory/Immune Signaling Pathway Programs
Toll-Like Receptors (TLRs) and NF-κB Program & Control of T Cell Subset Responses
As initiators of immune responses, TLRs sense microbes and exogenous ligands as well as endogenous ligands. TLR ligand recognition and binding leads to signaling responses which most often include NF-κB and/or interferon regulatory factors (IRF). Both pathways are major circuits driving activation of hundreds of genes, many of which are inflammatory mediators and immune response factors. There is a clear connection between TLRs and NF-κB/IRF signaling pathways in programming and driving specific normal adaptive immune responses as well as in the development and maintenance of inflammatory, autoinflammatory diseases and cancer.
IMGENEX portfolio provides the most comprehensive systems approach of products and assays for studying the NF-κB pathway activation components and TLR involvement in the cascade of immune and inflammatory activation. We are an abundant resource of products, platforms and expertise to take on exciting Research/Drug Discovery areas including:
- Discovery/Identification of pro-inflammatory or anti-inflammatory molecules
- Discovery/Characterization of Cytokine/Chemokine Signatures as response to ligands
- Characterization of Cytokine/Chemokine Signatures and T cell subset response
- Discovery/Characterization of new pathway points of intervention
Our Inflammatory/Immune Signaling Pathway Products and Services include a rapidly expanding portfolio validated for Flow Cytometry, Immunohistochemistry, Western Blotting and ELISA platforms.
- NF-κB SEAPorter Assay Kit flexible read-out system for the measurement of NF-κB activation by ELISA detection of secreted alkaline phosphatase (SEAP).
- TLR and TLR/NF-κB SEAPorter HEK293 Cells stably transfected reporter cell lines for a variety of screening assays
- New MyD88 specific mAb and other Adaptor Molecules
- NF-κB Inhibitor Reagents (Peptide Sets)
- TLRSystem™ of Cell analysis: Dendritic Cells and T Cell Network Analysis of CD Markers, TLR and Cytokine, Chemokine specific antibodies
- ActivELISA Kits and Reagents Inflammatory/Immune Mediator Quantitiation
- IMGENEX Screening Services which provides partnering opportunities utilizing our expertise for development of the specific assays you need for Inflammation and Immune Signaling Pathway analysis.
