New Product: Magnetofectamine O2 Transfection Kit

Magnetofectamine™ O2 is the new powerful and ideal transfection kit designed for primary and hard-to-transfect cells. The alliance of MTX transfection reagent and CombiMag leads to increased transfection efficiency, minimized toxicity and enhanced gene expression. Less nucleic acids used - Minimized toxicity. Reference.

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Bio X Cell bulk antibodies for in vivo research

With over 300 monoclonal antibodies covering a diverse range of research areas Bio X Cell is your source for purified bulk antibodies. Their reagent portfolio is specialized towards antibodies which are widely used for in vivo and in vitro antigen neutralization and pathway blockade as well as cell specific depletion. All Bio X Cell products are significantly discounted for customers from academia.

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HYPE-293 transfection reagent for Bioproduction

The new HYPE-293™ Transfection Kit of OZ Biosciences is dedicated to achieve High Yield Protein Expression in HEK-293, 293-S, 293-F or any 293-related cells growing in suspension. Scale-up to larger volumes for production of milligrams of protein per liter of cell culture is straightforward and easy with simple and cost efficient handling steps.

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New range of reverse transcription reagents

Solis BioDyne new FIREScript Reverse Transcriptase is a genetically engineered MMLV (Moloney Murine Leukemia Virus) based reverse transcriptase.

• 30 days stability at room temperature
• Fast and efficient, comparable to the best enzymes on the market
• Different formats available (mixes and kits)
• High working temperature up to 50°C
• High reproducibility
• For in vitro use only

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Evaluate the accuracy of your pipettes in seconds with Next Advance convenient Checkit cartridges.

Checkit instant pipette verification

Verification on the spot. Evaluate the accuracy of your pipettes in seconds with Next Advance convenient Pipette Checkit™ cartridges. Low-cost, fast, and easy to use, the Checkit can save money on calibration services while giving you the confidence that your pipettes are delivering accurate volumes. No more trying to read a tiny droplet’s weight on a high-precision balance.

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Immunometabolism & Inflammation research

AdipoGen Life Sciences develops and manufactures new products in the areas of cancer, immunology, (neuro)inflammation, metabolic syndrome (diabetes, obesity), stem cell biology and neurodegeneration. Major product lines are ELISA kits, (recombinant) antibodies, proteins, natural products and small molecules. AdipoGen is the expert in Inflammasome Signaling.

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Stelvio for Life

September 2nd 2017 the foundation Stelvio for Life organizes for the 6th time the climbing of one of the highest paved, most beautiful and most challenging mountains in Europe, the Stelvio Pass in Northern Italy.

If you also want to support our participants, please make a donation to the Bio-Connect team.

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GeneTex engages CRISPR/Cas9 technology to validate antibody specificity

At GeneTex, they continue to provide the research community with the highest quality and most stringently validated antibodies by engaging CRISPR/Cas9-mediated knockout technology. In a collaborative effort with EdiGene, a company that generates knockout or genome-edited cell lines using an innovative CRISPR/Cas9 methodology, GeneTex will use lysates made from these cell lines for western blot assays to confirm target specificity of their antibodies. This constitutes the “Knockout” arm of their "Knockout/Knockdown validation" initiative.

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Sino Biological proteins, antibodies, genes, and ELISA kits

Sino Biological manufactures high quality research reagents for basic, translational, and clinical research. Their portfolio includes proteins, antibodies, cDNAs, qPCR primers and ELISAs with a focus on immune checkpoints, targeted and immunotherapy, virology, cytokines, CD antigens, FC receptors, enzymes and kinases, growth factors, signal transduction, and biomarkers.

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Purify biomolecules? Use the LOABeads™ system!

A magnetic separation platform for proteins and antibodies based on magnetic agarose beads. Use it for immunoprecipitations, purification of monoclonal antibodies from cell culture, or your custom affinity purification. The LOABeads™ system is scalable from micro to ½ liter scale. The beads separate within seconds, resuspend even faster, and are clearly visible. With a capacity of 60 mg IgG/ml bead, LOABeads Protein A could be your preferred choice.

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Bio-Connect your antibody supplier

Whether you are looking for a good antibody against your target, your current antibody is discontinued, out of stock or simply not working do not worry! Bio-Connect can help you to secure your supply of antibodies to continue your research. See here our antibody suppliers with their antibody strengths.

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NxtGen Cancer Stem Cell Medium

PromoCell introduces the next generation Cancer Stem Cell Medium. This medium has been designed to meet your requirements for the extended serial 3D tumorsphere culture. The Cancer Stem Cell Medium supports the tumorsphere/mammosphere culture of the most commonly used cancer cell lines.

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High quality isolation and purification kits

DNA-Gdansk offers a selection of isolation kits that purify high quality genomic or plasmid DNA from a wide variety of sources and for a wide array of applications. They also offer RNA purification kits, PCR reagents including DNA thermostable polymerases, PCR enhancers, Master Mixes and deoxyribonucleotides.

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AdipoGen ELISA Kits

AdipoGen ELISA Kits for Key Biomarkers for Metabolic Syndrome, Inflammatory Diseases and Cancer & Autoimmune Diseases. AdipoGen Life Sciences is the original manufacturer of many widely used and cited ELISA Kits. AdipoGen Life Sciences is continuously developing ELISA Kits for new targets which are of interest to the research community. The AdipoGen Life Sciences ELISA Kits allow reproducible results with low inter- and intra-assay variation, show high sensitivity and can be used for a broad range of sample types.

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SeqPure PCR Purification System

Biochain’s SeqPure PCR Purification System is designed for rapid and efficient purification of PCR products. The system utilizes paramagnetic bead technology to selectively bind DNA fragments 100 bp and larger in size. Simple washing steps will remove salts, primers, primer-dimers, nucleotides, and enzymes prior to elution of the purified PCR product. The SeqPure DNA Purification System is ideal for purification of DNA using either manual procedures or automated liquid handling instruments.

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RBDs, new reagents for your discoveries in cell metabolism

Bio-Connect is happy to add the products of METAFORA biosystems to its portfolio. METAFORA is a biotechnology company which has specific products for your discoveries in cell metabolism.

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Dual Role of TGF-β in Cancer Promotion and Suppression

Transforming growth factor (TGF)-beta signaling can have either tumor-suppressing or tumor-promoting effects in a cell- and context-dependent manner. The canonical Smad pathway is responsible for most of the TGF-β biological responses leading to tumor suppression (growth arrest, apoptosis, and prevention of immortalization) and tumor promotion (EMT, migration, invasion, and metastasis).

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Caspase Detection

A central component of the apoptotic process is a cascade of proteolytic enzymes called caspases. Caspases participate in a series of reactions that are triggered in response to pro-apoptotic signals and result in the cleavage of protein substrates, causing the disassembly of the cell. Caspases have been identified in organisms ranging from... Read more »»

Merck (Millipore) provides a wide range of caspase antibodies, inhibitors, proteins and assays to help detect and study caspase activation in apoptotic cells.

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Linking NAD+ Signaling & Cancer

Many and various NAD+-dependent signaling pathways regulate fundamental processes such as transcription, DNA repair, cell cycle progression, apoptosis, proliferation, survival and metabolism, which are linked to cancer development. NAD+-dependent signaling reactions involve the degradation of NAD, therefore permanent nucleotide resynthesis through different biosynthetic pathways is crucial for incessant cancer cell proliferation. Targeting the NAD metabolism, its synthesis and signaling pathways (PARPs, SIRTs, MARTs, CD38) show several effects on cancer cells and are therefore new and promising concepts for cancer treatment.

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Excellent PTEN Antibody

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN is best known as a negative regulator of PI3K/AKT signaling by dephosphorylating PIP3. However, its functional shadow is now known to extend beyond PI3K/AKT pathway inhibition to include PIP3-independent roles affecting cell migration and genomic integrity. In addition, loss of normal PTEN activity has repercussions not only for tumor cell proliferation but also for regulation of the tumor microenvironment. Thus, there are clearly new frontiers to be explored in the PTEN field.

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Atlas Antibodies in Breast Cancer Research

Atlas is very active in the field of breast cancer research. A wide range of their antibodies are used by scientists working to understand breast cancer. A selection of polyclonal and monoclonal antibodies directed towards protein targets interesting for breast cancer research are P53, HER2, CD44, PGR and Ki-67.

Download the brochure here.

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