4-1BBL / CD137L antibody [N2C3]

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Product specifications for - 4-1BBL / CD137L antibody [N2C3]

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ImmunoPrecipitation; Western Blot
Species:	Human
Host:	Rabbit
Target:	TNFSF9
Target description:	TNF superfamily member 9
Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Controle:	A549 , HeLa , HepG2 , HCT116

Properties:
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Storage instructions:	2-¦C to 8-¦C, -20-¦C or -80-¦C

Scientific information:
Scientific info:	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Gene ID:	8744
Swiss prot ID:	P41273

Additional information:
Synonyms:	4-1BB ligand; 4-1BBL; 4-1BB-L; CD137L; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; TNLG5A; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9

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Product specifications for - 4-1BBL / CD137L antibody [N2C3]