AATF antibody

Catalog number: GTX85086_100ug
Brand: GeneTex
Packing: 100 ug
Price: € 448.00
Expected delivery time: 10 days
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Product specifications for - AATF antibody

Product group: Antibodies
Category: Primary Antibodies
Application: ELISA; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Western Blot
Species: Human, Mouse
Host: Rabbit
Target: AATF
Target description: apoptosis antagonizing transcription factor
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases (2). AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways (3). Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer's disease (AD) (4,5), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.
Gene ID: 26574
Swiss prot ID: Q9NY61
Additional information: 
Synonyms: Apoptosis-antagonizing transcription factor; BFR2; CHE1; CHE-1; DED; protein AATF; rb-binding protein Che-1