GTX107815 WB Image
Activin Receptor Type IA antibody
GTX107815
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameActivin Receptor Type IA antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.9 mg/ml
- IsotypeIgG
- Scientific DescriptionActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203