Overview
- SupplierGeneTex
- Product NameAIF antibody [N1C1]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice. Shen H et al., 2018, Front Aging NeurosciRead more
- Association between Cav3 channel upregulation in spiral ganglion neurons and age-dependent hearing loss. Geng Q et al., 2021 Aug, Exp GerontolRead more
- Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Lin SC et al., 2018 Feb, Oncol RepRead more
- NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival. Murata MM et al., 2019 Sep 15, Mol Biol CellRead more
- Pigment Epithelium-Derived Factor Mediates Autophagy and Apoptosis in Myocardial Hypoxia/Reoxygenation Injury. Kuo HF et al., 2016, PLoS OneRead more
- Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats. Ma C et al., 2016 Jan 1, Life SciRead more
- Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. Chen MF et al., 2016 Jul 26, BMC CancerRead more
- The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation. Shimada M et al., 2020 Aug 26, Sci RepRead more