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GTX113306 WB Image
GTX113306 WB Image
GTX113306 WB Image

AIF antibody [N1C1]

Research Use Only
GTX113306
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    AIF antibody [N1C1]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice. Shen H et al., 2018, Front Aging Neurosci
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  • Association between Cav3 channel upregulation in spiral ganglion neurons and age-dependent hearing loss. Geng Q et al., 2021 Aug, Exp Gerontol
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  • Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Lin SC et al., 2018 Feb, Oncol Rep
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  • NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival. Murata MM et al., 2019 Sep 15, Mol Biol Cell
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  • Pigment Epithelium-Derived Factor Mediates Autophagy and Apoptosis in Myocardial Hypoxia/Reoxygenation Injury. Kuo HF et al., 2016, PLoS One
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  • Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats. Ma C et al., 2016 Jan 1, Life Sci
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  • Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells. Chen MF et al., 2016 Jul 26, BMC Cancer
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  • The human papillomavirus E6 protein targets apoptosis-inducing factor (AIF) for degradation. Shimada M et al., 2020 Aug 26, Sci Rep
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