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GTX105620 ICC/IF Image
GTX105620 ICC/IF Image
GTX105620 ICC/IF Image

AKR1C1 antibody

Research Use Only
GTX105620
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    AKR1C1 antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.27 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting. Gupta R et al., 2017 Aug 1, Endocrinology
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  • AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer. Zhu H et al., 2018, Theranostics
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  • Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism. Zeng C et al., 2019, Front Physiol
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  • Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. Nomura M et al., 2011 Sep 3, J Clin Bioinforma
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  • Pro-inflammatory signals induce 20alpha-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal. Nadeem L et al., 2021 Jul, J Cell Mol Med
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  • The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer. Zhu H et al., 2020, Theranostics
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  • Upregulation of AKR1C1 in mesenchymal stromal cells promotes the survival of acute myeloid leukaemia cells. Jiang Y et al., 2020 May, Br J Haematol
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  • Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis. Marino N et al., 2020, NPJ Breast Cancer
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  • Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis. Marino N et al., 2020, NPJ Breast Cancer
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