Overview
- SupplierGeneTex
- Product NameAKR1C1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.27 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting. Gupta R et al., 2017 Aug 1, EndocrinologyRead more
- AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer. Zhu H et al., 2018, TheranosticsRead more
- Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism. Zeng C et al., 2019, Front PhysiolRead more
- Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. Nomura M et al., 2011 Sep 3, J Clin BioinformaRead more
- Pro-inflammatory signals induce 20alpha-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal. Nadeem L et al., 2021 Jul, J Cell Mol MedRead more
- The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer. Zhu H et al., 2020, TheranosticsRead more
- Upregulation of AKR1C1 in mesenchymal stromal cells promotes the survival of acute myeloid leukaemia cells. Jiang Y et al., 2020 May, Br J HaematolRead more
- Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis. Marino N et al., 2020, NPJ Breast CancerRead more
- Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis. Marino N et al., 2020, NPJ Breast CancerRead more