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AKT antibody [N3C2], Internal

Research Use Only
GTX121937
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    AKT antibody [N3C2], Internal
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.3 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • LDOC1 Suppresses Microbe-Induced Production of IL-1beta in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3beta Axis. Lee CH et al., 2020 Oct 27, Cancers (Basel)
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  • Pten loss in Lgr5+ hair follicle stem cells promotes SCC development. Chen H et al., 2019, Theranostics
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  • 3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFkappaB Signaling Pathways. Chao W et al., 2017 Mar 28, Molecules
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  • A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell. Terasaki M et al., 2021 Mar-Apr, Cancer Genomics Proteomics
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  • A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat Methods
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  • A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. Terasaki M et al., 2022, Nutr Cancer
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  • A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres. Ni YL et al., 2017 Oct, Apoptosis
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  • A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells. Hsieh CH et al., 2016, Drug Des Devel Ther
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  • Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells. Chen PC et al., 2018 Jun, J Cell Physiol
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  • AKT and its related molecular feature in aged mice skin. Chen H et al., 2017, PLoS One
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