GTX110613 ICC/IF Image
GTX110613 ICC/IF Image
AKT1 antibody
GTX110613
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameAKT1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.47 mg/ml
- IsotypeIgG
- Scientific DescriptionThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine. Lee KH et al., 2014 Sep 17, Sci RepRead more
- A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat MethodsRead more
- Copanlisib, a novel phosphoinositide 3-kinase inhibitor, combined with carfilzomib inhibits multiple myeloma cell proliferation. Okabe S et al., 2019 Mar, Ann HematolRead more
- Erythropoietin protects neuroblastoma cells against etoposide and vincristine by activating ERK and AKT pathways but has no effect in kidney cells. Vazquez-Mellado MJ et al., 2015 Sep 15, Life SciRead more
- MicroRNA-296 inhibits colorectal cancer cell growth and enhances apoptosis by targeting ARRB1-mediated AKT activation. Zhang Z et al., 2019 Jan, Oncol RepRead more
- The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling. Chen YJ et al., 2013 Dec, Gynecol OncolRead more