GTX112799 IHC-P Image
GTX112799 IHC-P Image
alpha Synuclein antibody
GTX112799
Product group Antibodies
Overview
- SupplierGeneTex
- Product Namealpha Synuclein antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.74 mg/ml
- IsotypeIgG
- Scientific DescriptionAlpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells. Kwon Y et al., 2020 Oct 17, Cell Death DisRead more
- Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinsons disease. Bastias-Candia S et al., 2015 May-Jun, Environ ToxicolRead more
- Exosomes from patients with Parkinsons disease are pathological in mice. Han C et al., 2019 Sep, J Mol Med (Berl)Read more
- MPTP-induced vulnerability of dopamine neurons in A53T alpha-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation. Lee S et al., 2017 Nov, Korean J Physiol PharmacolRead more
- Synthetic mRNA-based differentiation method enables early detection of Parkinsons phenotypes in neurons derived from Gaucher disease-induced pluripotent stem cells. Akiyama T et al., 2021 Apr, Stem Cells Transl MedRead more
- Transcriptomic analysis of alpha-synuclein knockdown after T3 spinal cord injury in rats. Zeng H et al., 2019 Nov 14, BMC GenomicsRead more