AMIGO-1 Antibody (OASE00286)

Aviva Systems Biology

AMIGO-1 Antibody (OASE00286)

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

Research Use Only

Monoclonal

S86-36

1 mg/ml

Unconjugated

AMIGO1

adhesion molecule with Ig like domain 1

ALI2; alivin-2; AMIGO; AMIGO-1; amphoterin-induced gene and ORF; amphoterin-induced protein 1

Mouse

IgG1

The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO1, AMIGO2 and AMIGO3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. They can form complexes with each other, but can also self-bind. AMIGO1, also designated Alivin2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO2 (Alivin1) is crucial for depolarization-dependent survival. Similar to AMIGO1 and AMIGO2, AMIGO3 (Alivin3) plays a role in hemophilic and/or heterophilic cell-cell interaction and signal transduction.

Human, Mouse, Rat

-20°C

12352203