AMPK Pathway Explorer Antibody MiniPack

Catalog number: 15-115
Brand: Merck
Packing: 3 vials
Price: € 272.00
Expected delivery time: 7 days

Product specifications for - AMPK Pathway Explorer Antibody MiniPack

Product group: Antibodies
Category: "Antibody pairs, sets and duo's"
Species: Human, Mouse, Rat
Host: Rabbit
Clonality: Polyclonal
  Research Use Only
UNSPSC: 12352203
Storage instructions: Stable for 1 year at -20-¦C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20-¦C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20-¦C may cause glycerol-containing solutions to become frozen during storage.
Scientific information: 
Scientific info: Pathway Explorer Antibody MiniPack:Each Pathway Explorer Antibody Minipack contains three related antibodies as part of a signaling cascade or a combination of total and phosphorylated forms of key signaling targets. Each of the three antibodies are 30% the original pack size. Full size versions of each of the Pathway Explorer antibodies are available for sale individually under the same catalog number with the removal of “SP” off of each one (e.g. 05-591SP can be ordered as 05-591). AMPK:AMP-activated protein kinase (AMPK) is a metabolic and stress-sensing kinase that regulates homeostasis, and a key target for treating Type 2 diabetes and obesity. AMPK exists as a heterotrimeric complex comprised of catalytic alpha subunits (62 kDa) and non-catalytic beta and gamma subunits. Alpha subunit has at least two isoforms (alpha 1 and alpha 2) which differ in their subcellular localization and AMP-dependence. AMPK is phosphorylated by upstream kinases, AMPK Kinase (AMPKK) and LKB1 which results in its activation. Active AMPK regulates metabolism by phosphorylating rate-limiting enzymes in metabolic pathways and controlling gene expression. Phosphorylation of threonine 172 in the activation loop of the alpha subunit is a key determinant of AMPK activity.See full size versions for corresponding references.
Additional information: 
Synonyms: 15-115; Merck (Millipore)