GTX29474 IHC-P Image
Androgen Receptor antibody [AR 441]
GTX29474
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
Overview
- SupplierGeneTex
- Product NameAndrogen Receptor antibody [AR 441]
- Delivery Days Customer10
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDAR 441
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedys disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1. Yokoyama A et al., 2021 Nov 1, J Endocr SocRead more
- Phospholipase C (PLC)epsilon Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line. Yuan M et al., 2019 Jun 15, Med Sci MonitRead more
- TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation. Onodera Y et al., 2016 Aug, Cancer MedRead more