anti-AIM2 (human), mAb (3B10)

AdipoGen Life Sciences

anti-AIM2 (human), mAb (3B10)

10

Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

3B10

1 mg/ml

>95%

AIM2

absent in melanoma 2

interferon-inducible protein AIM2; PYHIN4

Mouse

IgG1

AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16 [8], MNDA [9], AIM2 [1] and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta. - Monoclonal Antibody. Recognizes human AIM2. Isotype: Mouse IgG1. Clone: 3B10. Applications: ICC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.

Human

2°C to 8°C,-20°C

12352203