anti-alpha Actinin 4 antibody
ARG55162
ApplicationsWestern Blot
Product group Antibodies
ReactivityBovine, Chicken, Human, Mouse, Rat
TargetACTN4
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-alpha Actinin 4 antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID81
- Target nameACTN4
- Target descriptionactinin alpha 4
- Target synonymsACTININ-4; alpha-actinin-4; focal segmental glomerulosclerosis 1; FSGS; FSGS1; non-muscle alpha-actinin 4
- HostRabbit
- IsotypeIgG
- Scientific DescriptionAlpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
- ReactivityBovine, Chicken, Human, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203