anti-APAF1 antibody

Arigo Biolaboratories

anti-APAF1 antibody

23

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

APAF1

apoptotic peptidase activating factor 1

APAF-1; apoptotic protease-activating factor 1; CED4

Rabbit

IgG

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 is ubiquitously expressed in human tissues.

Human

-20°C

12352203