anti-BAFF (mouse), mAb (blocking) (Sandy-2) | AG-20B-0063-C100 | AdipoGen Life Sciences - Bio-Connect

Product specifications for - anti-BAFF (mouse), mAb (blocking) (Sandy-2)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ImmunoPrecipitation; Neutralisation/Blocking
Species:	Mouse
Host:	Mouse
Target:	Tnfsf13b
Target description:	tumor necrosis factor (ligand) superfamily, member 13b
Clonality:	Monoclonal
Isotype:	IgG1

Properties:
Purity:	>95% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Form supplied:	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:	2-¦C to 8-¦C

Scientific information:
Scientific info:	BAFF is a master regulator of peripheral B cell survival and, together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjogrens syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL). - Monoclonal Antibody. Recognizes mouse BAFF. Isotype: Mouse IgG1. Clone: Sandy-2. Applications: FUNC (Blocking), IP. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. BAFF is a master regulator of peripheral B cell survival and, together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjogrens syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
Clone ID:	Sandy-2
Gene ID:	24099
Swiss prot ID:	Q9WU72

Safety information:
MSDS:	MSDS
Hazard information:	Non-hazardous

Additional information:
Synonyms:	AG-20B-0063-C100; AdipoGen Life Sciences; b cell-activating factor; BAFF; B-cell-activating factor; BLyS; D8Ertd387e; TALL1; TALL-1; THANK; TNFSF20; Tnlg7a; tumor necrosis factor ligand 7a; tumor necrosis factor ligand superfamily member 13B; zTNF4

The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis: T. Abe, et al.; J. Immunol. 195, 1427 (2015)

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Antibodies that block or activate mouse B cell activating factor of the TNF family (BAFF) respectively induce B cell depletion or B cell hyperplasia: C. Kowalczyk-Quintas, et al.; J. Biol. Chem. 291, 19826 (2016)

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