anti-BAFF (mouse), mAb (blocking) (Sandy-2)

Product specifications for - anti-BAFF (mouse), mAb (blocking) (Sandy-2)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	FUNC (Blocking), ImmunoPrecipitation
Clonality:	Monoclonal
Isotype:	IgG1
Source:	Purified from concentrated hybridoma tissue culture supernatant.

Properties:
Purity:	>95% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1mg/ml
Form supplied:	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:	Store at -20°C

Scientific information:
Scientific info:	BAFF is a master regulator of peripheral B cell survival and, together with IL-6, promotes Ig class-switching and plasma cell differentiation. BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren s syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).
Clone ID:	Sandy-2
Swiss prot ID:	Q9WU72

Safety information:
MSDS:	MSDS

Additional information:
Synonyms:	AG-20B-0063-C100; AdipoGen Life Sciences; BLyS; TALL-1; CD257; B Cell Activating Factor; TNFSF13B

The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis: T. Abe, et al.; J. Immunol. 195, 1427 (2015)

Antibodies that block or activate mouse B cell activating factor of the TNF family (BAFF) respectively induce B cell depletion or B cell hyperplasia: C. Kowalczyk-Quintas, et al.; J. Biol. Chem. 291, 19826 (2016)

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Product specifications for - anti-BAFF (mouse), mAb (blocking) (Sandy-2)