anti-BTLA (human), mAb (6F4)

Catalog number: AG-20B-0049-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 360.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-BTLA (human), mAb (6F4)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ELISA; Flow Cytometry; Neutralisation/Blocking
Species: Human
Target: BTLA
Target description: B and T lymphocyte associated
Isotype: IgG1
Source: Purified from concentrated hybridoma tissue culture supernatant.
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol.
Storage instructions: -20-¦C
Scientific information: 
Scientific info: B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM. - Monoclonal Antibody. Recognizes human BTLA. Isotype: Rat IgG1. Clone: 6F4. Applications: ELISA, FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol. B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.
Clone ID: 6F4
Gene ID: 151888
Swiss prot ID: Q7Z6A9
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA1; CD272
T Cell Intrinsic Heterodimeric Complexes between HVEM and BTLA Determine Receptivity to the Surrounding Microenvironment: T.C. Cheung, et al.; J. Immunol. 183, 7286 (2009) Read more
Unconventional ligand activation of herpesvirus entry mediator signals cell survival: T.C. Cheung, et al.; PNAS 106, 6244 (2009) Read more