anti-Cardif (human), mAb (Adri-1)

AdipoGen Life Sciences

anti-Cardif (human), mAb (Adri-1)

10

ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

Research Use Only

Monoclonal

Adri-1

1 mg/ml

>95%

MAVS

mitochondrial antiviral signaling protein

CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; CARDIF; IFN-B promoter stimulator 1; interferon beta promoter stimulator protein 1; IPS1; IPS-1; mitochondrial antiviral-signaling protein; putative NF-kappa-B-activating protein 031N; virus-induced signaling adaptor; virus-induced-signaling adapter; VISA

Mouse

IgG2b

Monoclonal Antibody. Recognizes human Cardif. Isotype: Mouse IgG2b. Clone: Adri-1. Applications: ICC, IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production. - RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.

Human

2°C to 8°C,-20°C

12352203