anti-Caspase-11 (mouse), mAb (4E11)

Catalog number: AG-20T-0140-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 310.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-Caspase-11 (mouse), mAb (4E11)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ELISA; Flow Cytometry; ImmunoPrecipitation; Western Blot
Species: Mouse, Rat
Target: Casp4
Target description: caspase 4, apoptosis-related cysteine peptidase
Isotype: IgG1 Kappa
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 0.02% sodium azide.
Storage instructions: -20-¦C
Scientific information: 
Scientific info: Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. - Monoclonal Antibody. Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot. Isotype: Rat IgG1kappa. Clone: 4.00E+11. Applications: ELISA, FACS, IP, WB. Liquid. In PBS containing 0.02% sodium azide. Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.
Clone ID: 4E11
Gene ID: 12363
Swiss prot ID: P70343
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: Casp11; CASP-11; CASP-4; caspase 11, apoptosis-related cysteine peptidase; caspase 11, apoptosis-related cysteine protease; caspase 4, apoptosis-related cysteine protease; Caspase-11; caspase-11 short form splicing; caspase-4; Caspl; ich-3; protease ICH-3
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006) Read more
Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases: M.F. Van Delft, et al.; Cell Death Differ. 17, 821 (2010) Read more