anti-CD105 / Endoglin antibody [MEM-226]

Arigo Biolaboratories

anti-CD105 / Endoglin antibody [MEM-226]

23

Flow Cytometry, ImmunoPrecipitation, Western Blot, Other Application

Research Use Only

Monoclonal

MEM-226

1 mg/ml

Unconjugated

>95%

ENG

endoglin

CD105 antigen; END; endoglin; HHT1; ORW1

Mouse

IgG2a

CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.

Human

-20°C

12352203