anti-CD117 / c-Kit antibody [104D2] (PE)
ARG54188
ApplicationsFlow Cytometry
Product group Antibodies
TargetKIT
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD117 / c-Kit antibody [104D2] (PE)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID104D2
- ConjugateRPE
- Gene ID3815
- Target nameKIT
- Target descriptionKIT proto-oncogene, receptor tyrosine kinase
- Target synonymsCD117; C-Kit; c-Kit protooncogene; mast/stem cell growth factor receptor Kit; MASTC; p145 c-kit; PBT; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; soluble KIT variant 1; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.
- Storage Instruction2°C to 8°C
- UNSPSC12352203