anti-CD158d / KIR2DL4 antibody [mAb#33]

Arigo Biolaboratories

anti-CD158d / KIR2DL4 antibody [mAb#33]

23

Functional Assay, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

mAb#33

1 mg/ml

Unconjugated

>95%

KIR2DL4

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

CD158 antigen-like family member D; CD158D; G9P; killer cell immunoglobulin-like receptor 2DL4; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4; killer cell inhibitory receptor 103AS; KIR103; KIR103AS; KIR-103AS; KIR-2DL4; KIR2DL4 Killer-cell Immunoglobulin-like Receptor; KIR2DL4_00201; KIR2DL4_00201 protein; MHC class I NK cell receptor KIR103AS

Mouse

IgG1

CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.

-20°C

12352203