anti-CD180 / RP105 antibody [G28-8]

Arigo Biolaboratories

anti-CD180 / RP105 antibody [G28-8]

23

Functional Assay, Flow Cytometry, ImmunoPrecipitation

Research Use Only

Monoclonal

G28-8

1 mg/ml

Unconjugated

>95%

CD180

CD180 molecule

CD180 antigen; LY64; Ly78; lymphocyte antigen 64; lymphocyte antigen-64, radioprotective, 105kDa; radioprotective 105 kDa protein; RP105

Mouse

IgG1

CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.

Human

-20°C

12352203