anti-CD195 / CCR5 antibody
ARG54318
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetCCR5
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD195 / CCR5 antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1234
- Target nameCCR5
- Target descriptionC-C motif chemokine receptor 5
- Target synonymsC-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5; CCR-5; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemokine recptor CCR5 Delta32; chemr13; CKR5; CKR-5; CMKBR5; HIV-1 fusion coreceptor; IDDM22; mutant C-C motif chemokine receptor
- HostRabbit
- IsotypeIgG
- Scientific DescriptionHuman immunodeficiency virus (HIV) and related viruses require coreceptors in addition to CD4 to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, Bonzo, GPR1, and V28, have been identified as HIV coreceptors. Among them, CCR5 is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains. CCR5 is required for infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-1alpha, and MIP-1beta are the ligands for CCR5 and prevent infection by macrophage-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites. Messenger RNA for CCR5 is expressed in lymphoid cells and tissues.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203