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anti-CD200 antibody [OX-104] (APC)

Research Use Only
ARG54292
Arigo Biolaboratories
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetCD200
Price on request
Packing Size
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-CD200 antibody [OX-104] (APC)
  • Delivery Days Customer
    23
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    OX-104
  • Conjugate
    APC
  • Gene ID4345
  • Target name
    CD200
  • Target description
    CD200 molecule
  • Target synonyms
    antigen identified by monoclonal antibody MRC OX-2; CD200 antigen; MOX1; MOX2; MRC; OX-2; OX-2 membrane glycoprotein
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    CD200 (also known as OX2 or MRC) is a type-1 membrane glycoprotein, which contains two extracellular immunoglobulin domains, transmembrane domain and cytoplasmic domain. It is expressed by neuronal cells, B and T cell subsets, follicular dendritic cells, keratinocytes, and ovarian cells. The interaction between CD200 and its receptor CD200R results in macrophage activation (IL-6 production), inhibition of mast cell degranulation along with reduced TNF-alpha and IL-13 secretion and overall attenuation of the activation status of lymphocytes. It seems CD200 is also involved in maternal tolerance and its decreased expression in hair follicle correlates with follicular miniaturization.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203