anti-CD21 antibody [LT21]

Arigo Biolaboratories

anti-CD21 antibody [LT21]

23

Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

LT21

1 mg/ml

Unconjugated

>95%

CR2

complement C3d receptor 2

C3DR; CD21; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor type 2; CR; CVID7; EBV receptor; SLEB9

Mouse

IgG1

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.

Human

-20°C

12352203