anti-CD222 / IGF2R antibody [MEM-238] (FITC)
ARG62778
ApplicationsFlow Cytometry
Product group Antibodies
TargetIGF2R
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD222 / IGF2R antibody [MEM-238] (FITC)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMEM-238
- ConjugateFITC
- Gene ID3482
- Target nameIGF2R
- Target descriptioninsulin like growth factor 2 receptor
- Target synonyms300 kDa mannose 6-phosphate receptor; cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; CI-M6PR; CIMPR; IGF-II receptor; insulin-like growth factor II receptor; M6P/IGF2 receptor; M6P/IGF2R; M6P-R; MPR 300; MPR1; MPR300; MPRI
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
- Storage Instruction2°C to 8°C
- UNSPSC12352203