anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01]

Arigo Biolaboratories

anti-CD264 / TRAIL R4 antibody [TRAIL-R4-01]

23

Flow Cytometry

Research Use Only

Monoclonal

TRAIL-R4-01

1 mg/ml

Unconjugated

>95%

TNFRSF10D

TNF receptor superfamily member 10d

CD264; DCR2; decoy receptor 2; TNF receptor-related receptor for TRAIL; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAILR4; TRAIL-R4; TRUNDD; tumor necrosis factor receptor superfamily member 10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain

Mouse

IgG1

TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).

-20°C

12352203