anti-CD278 (human), Rabbit Monoclonal (RM417)

Catalog number: REV-31-1303-00-R100
Brand: RevMab
Packing: 100 ul
Price: € 380.00
Expected delivery time: 7 days
Quantity:
Immunohistochemical staining of for...

Product specifications for - anti-CD278 (human), Rabbit Monoclonal (RM417)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoHistoChemistry
Species: Human
Host: Rabbit
Target: ICOS
Target description: inducible T cell costimulator
Clonality: Monoclonal
Isotype: IgG
Properties: 
Purity: Protein A affinity purified from an animal origin-free culture supernatant.
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Storage instructions: -20-¦C
Scientific information: 
Scientific info: CD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. - Recombinant Antibody. This antibody reacts to human CD278. Applications: IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
Clone ID: RM417
Gene ID: 29851
Swiss prot ID: Q9Y6W8
Safety information: 
Hazard information: Non-hazardous
Additional information: 
Synonyms: activation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CVID1; inducible costimulator; inducible T-cell costimulator; inducible T-cell co-stimulator