anti-CD278 (human), Rabbit Monoclonal (RM417)

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Immunohistochemical staining of for...

Product specifications for - anti-CD278 (human), Rabbit Monoclonal (RM417)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ImmunoHistoChemistry
Species:	Human
Host:	Rabbit
Target:	ICOS
Target description:	inducible T cell costimulator
Clonality:	Monoclonal
Isotype:	IgG

Properties:
Purity:	Protein A affinity purified from an animal origin-free culture supernatant.
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Storage instructions:	-20-¦C

Scientific information:
Scientific info:	CD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. - Recombinant Antibody. This antibody reacts to human CD278. Applications: IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
Clone ID:	RM417
Gene ID:	29851
Swiss prot ID:	Q9Y6W8

Safety information:
Hazard information:	Non-hazardous

Additional information:
Synonyms:	activation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CVID1; inducible costimulator; inducible T-cell costimulator; inducible T-cell co-stimulator

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anti-CD278 (human), Rabbit Monoclonal (RM417)

Product specifications for - anti-CD278 (human), Rabbit Monoclonal (RM417)