anti-CD278 (human), Rabbit Monoclonal (RM417)

RevMAb Biosciences

anti-CD278 (human), Rabbit Monoclonal (RM417)

5

ImmunoHistoChemistry

Research Use Only

Monoclonal

RM417

ICOS

inducible T cell costimulator

activation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CVID1; inducible costimulator; inducible T-cell costimulator; inducible T-cell co-stimulator

Rabbit

IgG

CD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. - Recombinant Antibody. This antibody reacts to human CD278. Applications: IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.

Human

-20°C

12352203