anti-CD28 (human), mAb (ANC28.1/5D10)

Catalog number: ANC-177-020
Brand: Ancell Corporation
Packing: 100 ug
Price: € 195.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-CD28 (human), mAb (ANC28.1/5D10)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ELISA; Flow Cytometry; Functional Assay
Species: Human
Isotype: IgG1 Kappa
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Storage instructions: 2-¦C to 8-¦C
Scientific information: 
Scientific info: Human CD28 is an important costimulatory molecule found on all CD4+ T cells and on about half of the CD8+ T cells. T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. The ligands for CD28 identified as CD80 (B7-1) and CD86 (B7-2) are immunglobulin superfamily monomeric transmembrane glycoproteins of 60kDa and 80kDa respectively. Anti-CD28 antibodies have been shown to have a strong adjuvant effect when conjugated to an immunogen. Monovalency of the CD28 receptor for its natural ligands is essential to provide costimulation without inducing responses in the absense of TCR engagement. - Monoclonal Antibody. Isotype: Mouse IgG1kappa. Clone: ANC28.1/5D10. Applications: ELISA, FACS, FUNC. 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate Human CD28 is an important costimulatory molecule found on all CD4+ T cells and on about half of the CD8+ T cells. T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. The ligands for CD28 identified as CD80 (B7-1) and CD86 (B7-2) are immunglobulin superfamily monomeric transmembrane glycoproteins of 60kDa and 80kDa respectively. Anti-CD28 antibodies have been shown to have a strong adjuvant effect when conjugated to an immunogen. Monovalency of the CD28 receptor for its natural ligands is essential to provide costimulation without inducing responses in the absense of TCR engagement.
Clone ID: ANC28.1/5D10