anti-CD3 epsilon antibody [145-2C11] (APC)
ARG62808
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application
Product group Antibodies
ReactivityMouse
TargetCd3e
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD3 epsilon antibody [145-2C11] (APC)
- Delivery Days Customer23
- ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID145-2c11
- Concentration0.1 mg/ml
- ConjugateAPC
- Gene ID12501
- Target nameCd3e
- Target descriptionCD3 antigen, epsilon polypeptide
- Target synonymsAI504783; CD3; CD3epsilon; T3e; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain
- HostHamster
- IsotypeIgG1
- Scientific DescriptionCD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203