anti-CD314 antibody [1D11] (FITC)

Arigo Biolaboratories

anti-CD314 antibody [1D11] (FITC)

23

Flow Cytometry

Research Use Only

Monoclonal

1D11

FITC

KLRK1

killer cell lectin like receptor K1

CD314; D12S2489E; killer cell lectin-like receptor subfamily K, member 1; KLR; NK cell receptor D; NKG2D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor

Mouse

IgG1

CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). CD314 homodimers are associated with DAP10, a membrane adaptor protein that signals similar to CD28 by recruitment of phosphatidylinositol 3-kinase. Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. In NK cells, CD314 is a primary activating receptor. As CD314 ligands the MHC class-I chain-related proteins A and B (MICA, MICB) and UL16-binding proteins (ULBPs) have been identified.

2°C to 8°C

12352203