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anti-CD40 (human), mAb (EA-5) (R-PE)

Research Use Only
ANC-300-050
Ancell Corporation
ApplicationsFunctional Assay, Flow Cytometry, ELISA
Product group Antibodies
ReactivityHuman, Rat
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Ancell Corporation
  • Product Name
    anti-CD40 (human), mAb (EA-5) (R-PE)
  • Delivery Days Customer
    10
  • Applications
    Functional Assay, Flow Cytometry, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    EA-5
  • Conjugate
    RPE
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkins and Hodgkins lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. - Monoclonal Antibody. Isotype: Mouse IgG1. Clone: EA-5. Applications: ELISA, FACS, FUNC. 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative). CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkins and Hodgkins lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
  • Reactivity
    Human, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203