anti-CD45R / B220 antibody [IVA103]
ARG62860
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry
Product group Antibodies
TargetPTPRC
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD45R / B220 antibody [IVA103]
- Delivery Days Customer23
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDIVA103
- Concentration1 mg/ml
- ConjugateUnconjugated
- Estimated Purity>95%
- Gene ID407152
- Target namePTPRC
- Target descriptionprotein tyrosine phosphatase receptor type C
- Target synonymscd45; membrane tyrosine phosphatase; receptor-type tyrosine-protein phosphatase C
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
- Storage Instruction-20°C
- UNSPSC12352203