anti-CD52 antibody [HI186]

Arigo Biolaboratories

anti-CD52 antibody [HI186]

23

Flow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application

Research Use Only

Monoclonal

HI186

1 mg/ml

Unconjugated

>95%

CD52

CD52 molecule

cambridge pathology 1 antigen; CAMPATH-1 antigen; CD52 antigen (CAMPATH-1 antigen); CDW52; CDW52 antigen (CAMPATH-1 antigen); EDDM5; epididymal secretory protein E5; epididymis secretory sperm binding protein Li 171mP; HE5; HEL-S-171mP; human epididymis-specific protein 5

Mouse

IgG2b

CD52 (CAMPATH-1, HE5) is a highly glycosylated GPI-anchored 21-28 kDa glycopeptide which is present at high levels on lymphocytes, macrophages, epithelial cells of male reproductive tract and mature sperm. Its 12-amino acid beckbone carries a complex N-linked carbohydrate moiety, which differs between sperm and leukocyte CD52, as well as the GPI anchor does. CD52 can be acquired by sperm cells from seminal plasma, where it is released by epithelial cells. Although CD52 is not an essential T-cell costimulator, its triggering results in activation of normal human T cells. CD52 is a very good target for antibody/complement-mediated cell lysis.

Human

-20°C

12352203