anti-CD8b antibody [341]

Arigo Biolaboratories

anti-CD8b antibody [341]

23

Functional Assay, Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

341

1 mg/ml

Unconjugated

>95%

Cd8b

CD8b molecule

CD8 antigen 37 kDa chain; CD8 antigen beta-chain; Cd8b1; OX-8 membrane antigen; T-cell surface glycoprotein CD8 beta chain

Mouse

IgG1

The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

-20°C

12352203