anti-CD95 / Fas antibody [LT95] (FITC)
ARG62952
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetFAS
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-CD95 / Fas antibody [LT95] (FITC)
- Delivery Days Customer23
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDLT95
- ConjugateFITC
- Gene ID355
- Target nameFAS
- Target descriptionFas cell surface death receptor
- Target synonymsALPS1A; APO-1; APO-1 cell surface antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas AMA; FAS1; FASLG receptor; FASTM; mutant tumor necrosis receptor superfamily member 6; TNF receptor superfamily member 6; TNFRSF6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203