anti-CSK antibody [CSK-04]

Arigo Biolaboratories

anti-CSK antibody [CSK-04]

23

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

CSK-04

Unconjugated

>95%

CSK

C-terminal Src kinase

CSK, non-receptor tyrosine kinase; C-Src kinase; c-src tyrosine kinase; protein-tyrosine kinase CYL; tyrosine-protein kinase CSK

Mouse

IgG1

C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase which resembles Src-family kinases, but unlike them lacks the conserved autophosphorylation site, the regulatory C-terminal tyrosine as well as myristylation and palmitylation. Csk negatively regulates Src-family kinases by phosphorylation of their C-terminal regulatory tyrosine. Disruption of the csk gene causes constitutive activation of Src-family kinases, and overexpression of Csk usually counteracts their signaling. The Csk-mediated regulation of those Src-family kinases that are localized in lipid rafts is enabled by a ubiquitously expressed transmembrane adaptor PAG (also known as Cbp, Csk-binding protein), which recruits Csk.

Human

-20°C

12352203