anti-DcR3 antibody

Arigo Biolaboratories

anti-DcR3 antibody

23

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

TNFRSF6B

TNF receptor superfamily member 6b

DCR3; decoy receptor 3 variant 1; decoy receptor 3 variant 2; decoy receptor for Fas ligand; DJ583P15.1.1; M68; M68E; TR6; tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily, member 6b, decoy

Rabbit

IgG

Several novel members in the TNF receptor family, including DR3, DR4, DR5 and DR6, function as cell death receptors. Two decoy receptors, DcR1 and DcR2, compete with DR4 and DR5 for binding of their ligand, TRAIL. Another decoy receptor, DcR3/TR6 was discovered recently. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane-associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL- and LIGHT-induced apoptosis. DcR3 transcript is expressed in some lung and colon carcinomas and in some normal tissues.

Human

-20°C

12352203