anti-DFFB / DFF40 / CAD antibody

Arigo Biolaboratories

anti-DFFB / DFF40 / CAD antibody

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

Dffb

DNA fragmentation factor, beta subunit

40kD; 40kDa; 5730477D02Rik; C; CA; CAD; caspase-activated deoxyribonuclease; caspase-activated DNase; CPAN; DFF40; DFF-40; Didf; Didff; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor subunit beta; DNA fragmentation factor, 40 kD, beta subunit; DNase inhibited by DNA fragmentation factor

Rabbit

IgG

Cell death signals are transduced by death domain-containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse Dnase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxy-ribonuclease). The human homologue of mouse CAD was more recently identified and termed CPAN, DFF40, and human CAD. DFF45/ICAD is the inhibitory protein of DFF40/CAD with which it forms complexes. Upon cleavage by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD is, which causes DNA degradation, is the hallmark of apoptotic cell death.

Mouse

-20°C

12352203