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anti-ERBB2 / HER2 antibody

Research Use Only
ARG54982
Arigo Biolaboratories
ApplicationsWestern Blot
Product group Antibodies
ReactivityMouse
TargetErbb2
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-ERBB2 / HER2 antibody
  • Delivery Days Customer
    23
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID13866
  • Target name
    Erbb2
  • Target description
    erb-b2 receptor tyrosine kinase 2
  • Target synonyms
    avian erythroblastosis oncogene B 2; c-erbB; c-erbB2; c-erbB-2; c-ne; c-neu; ErbB-; Erbb-2; HER; HER-; HER2; HER-2; l11Ju; l11Jus8; mKIAA3023; Ne; Neu; Neu oncogene; p185erbB2; proto-oncogene c-ErbB-2; proto-oncogene NEU; receptor tyrosine-protein kinase erbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
  • Reactivity
    Mouse
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203