anti-IL-1alpha (mouse), mAb (Bamboo-2)

Catalog number: AG-20B-0058-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 330.00
Expected delivery time: 7 days

Product specifications for - anti-IL-1alpha (mouse), mAb (Bamboo-2)

Product group: Antibodies
Category: Primary Antibodies
Application: ELISA
Clonality: Monoclonal
Isotype: IgG1 Kappa
Source: Purified from concentrated hybridoma tissue culture supernatant.
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Clone ID: Bamboo-2
Swiss prot ID: P01582
Safety information: 
Additional information: 
Synonyms: AG-20B-0058-C100; AdipoGen Life Sciences; Interleukin-1alpha